Ramp down tip

As you wrap up your paid gig for awhile, write yourself a quick note to be opened on a specific date a few months before you return to work. In the note, jot down at least 3 options of where you'd like to see yourself go, career-wise, upon your return. When the time comes, use this letter to yourself as a springboard towards choosing your next career step.
-Alexandra Jenkins

If you resign prior to vesting, make sure you are clear about what (if anything) you will be leaving on the table. Check into stock options, tenure, retirement, bonuses and any other financial benefits that may be effected. You may find that staying a bit longer can offer a significant financial perk.
-Ilene Schaffer

Consider a leave of absence instead of quitting your job; this allows for an easier return to work when you're ready.

When taking a break from the paid workforce, keep in touch
periodically with at least a few colleagues who've been supportive in
the past. This will ensure that your career network is active whenever
you need it.

If you want to off-ramp, consider slowing down as opposed to stopping cold turkey.  Keeping one foot in the door will keep you marketable and connected to your industry.  Consider creating a plan that gives you flexibility to pursue the life you want outside of employment while at the same time maintaining your skill set.